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探讨白介素－２（ＩＬ－２）、白介素－２受体（ＩＬ－２Ｒ）与小儿肾病综合征病理类型关系。方法利用体外淋巴细胞培养方法，检测了小儿肾病综合征（ＮＳ）外周血淋巴细胞诱生白细胞介素－２（ＩＬ－２）能力及受体（ＩＬ－２Ｒ）的表达。结果小儿ＮＳ外周血ＩＬ－２的诱生与正常对照组无显著性差异（Ｐ＞０．０５）；而ＩＬ－２Ｒ表达较正常对照组明显增强（Ｐ＜０．０１），且与患儿肾脏病理形态改变有一定的关系。结论小儿ＮＳ患者ＩＬ－２Ｒ表达异常与肾脏病理类型之间具有某种内在联系。
To investigate the relationship between interleukin-2 (IL-2), interleukin-2 receptor (IL-2R) and pathological type of nephrotic syndrome in children. Methods The in vitro lymphocyte culture method was used to detect the expression of interleukin-2 (IL-2) and its receptor (IL-2R) in peripheral blood lymphocytes of children with nephrotic syndrome (NS). Results There was no significant difference in IL-2 induced by NS peripheral blood in children (P> 0.05), while the expression of IL-2R in NS was significantly higher than that in normal controls (P <0.01) Kidney pathological changes have a certain relationship. Conclusion The abnormal expression of IL-2R in pediatric NS patients has some intrinsical relationship with the pathological type of kidney.