AIM: To explore the effect of Hejie decoction (HJD) (mediationdecoction) on T cellular immune state of chronic hepatitisB patients.METHODS: Sixty-five patients with chronic hepatitis B wererandomly divided into 2 groups.Forty patients in the treatmentgroup were treated by HJD,and 25 patients in the controlgroup were treated by routine Western medicine.The TCRVβ_7gene expression,T lymphocyte subsets (CD_3~+,CD_4~+,CD_8~+,CD_4~+/CD_8~+) levels were observed before and after treatment.RESULTS: The level of CD_4~+ cells was lower whereas thelevel of CD_8~+ cells was higher in patients than in the normalgroup.There was no significant difference between thelevels of CD_3~+ cells in patients and normal persons.After 6months of treatment,ALT,AST,TB levels of the 2 groupswere obviously decreased,and the level of CD_4~+ cells wasincreased whereas the level of CD_8~+ cells was decreasedin the treatment group.However,the level of CD_4~+ cellsand CD_8~+ cells had no significant difference in the controlgroup.TCRVβ_7 expressions were detected in 6 patients ofthe treatment group,whose HBV-DNA and HBeAg turnednegative and ALT became normal.HBeAg in another 3patients turned negative while HBV-DNA did not,andTCRVβ_7 expressions were not detectable.TCRVβ_7 expressioncould not be detected in the control group,HBV-DNA of thecontrol group did not turn negative.HBeAg in 1 patientturned negative while HBV-DNA did not,and TCRVβ_7expressions were not detectable.The total effectiverate was not significantly different between the 2 groupsand the markedly effective rate was significantly different(P<0.01).CONCLUSION: HJD is effective for treating chronic hepatitisB,and its effect seems to relate with the improvement ofthe TCRVβ_7 expression of chronic hepatitis B patients,thusactivating T cells and eliminating HBV.T cellular immunefunction plays an important role in HBV infection and viruselimination. AIM: To explore the effect of Hejie decoction (HJD) (mediation de coction) on T cellular immune state of chronic hepatitis B patients. METHODS: Sixty-five patients with chronic hepatitis B wererandomly divided into 2 groups. Forty patients in the treatment group were treated by HJD , and 25 patients in the control group were treated by routine Western medicine. TCRVβ_7gene expression, T lymphocyte subsets were observed before and after treatment (CD_3 ~ +, CD_4 ~ +, CD_8 ~ +, CD_4 ~ + / CD_8 ~ +) RESULTS: The level of CD_4 ~ + cells was lower than the level of CD_8 ~ + cells was higher in patients than in the normal group. There was no significant difference between the levels of CD_3 ~ + cells in patients and normal persons. After 6 months of treatment, ALT, AST, TB levels of the 2 groupswere obviously decreased, and the level of CD_4 ~ + cells wasincreased compared with the level of CD_8 ~ + cells was decreased in the treatment group.However, the level of CD_4 ~ + cellsand CD_8 ~ + cells had no significant difference in the c ontrolgroup.TCRVβ_7 expressions were detected in 6 patients of the treatment group, whose HBV-DNA and HBeAg turnednegative and ALT became normal. HBeAg in another 3patients turned negative while HBV-DNA did not, andTCRVβ_7 expressions were not detectable.TCRVβ_7 expressioncould not be detected in the control group, HBV-DNA of the control group did not turn negative. HBeAg in 1 patient turned negative while HBV-DNA did not, and TCRVβ_7expressions were not detectable. The total effective rate was not significantly different between the two groups and the markedly effective rate was significantly different (P <0.01). CONCLUSION: HJD is effective for treating chronic hepatitis B, and its effect seems to relate with the improvement of the TCRVβ_7 expression of chronic hepatitis B patients, thus activating T cells and eliminating HBV.T cellular immunefunction plays an important role in HBV infection and viruselimination.