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应用组织学、组织化学和电镜方法研究了３０例癫痫病人病灶区手术切除标本脑组织的形态学和神经递质变化。发现引起癫痫发作的多种病灶（如胶质瘤、胶质疤痕、肉芽组织、血管畸形、寄生虫病等）除该疾病所特有的病理形态学改变外，还具有共同的神经形态学和神经递质改变：神经细胞核固缩、染色质边集、核周质水肿、尼氏质减少或消失、胞体皱缩、数量减少。同时，星形胶质细胞和小胶质细胞大量增生。尤其值得注意的是，在大多数病灶区增生的胶质细胞呈谷氨酸免疫反应。我们认为：这提示在慢性癫痫情况下，胶质细胞合成、贮存的摄取谷氨酸的能力增强。因而，即使在病灶区神经细胞受损、数量减少的情况下，仍能保持一个相当大的谷氨酸库，并可在一定的因素诱导下，释放至周围脑组织，导致癫痫的再发作。本研究为慢性癫痫的反复发作提供了可能的神经化学依据。
The changes of morphology and neurotransmitter in 30 cases of surgical resection specimens of epilepsy patients were studied by histology, histochemistry and electron microscopy. In addition to the pathological changes that are characteristic of this disease, various lesions that cause seizures (such as glioma, glial scar, granulation tissue, vascular malformations, parasitic diseases, etc.) have been found to have common neuromorphology and nerves Neurotransmitter changes: nuclear pyknosis of the nucleus, chromatin marginalization, periplasmic edema, reduction or disappearance of Nissl, cell shrinkage, the number decreased. Meanwhile, astrocytes and microglial cells proliferate. Of particular note is that glutamate-immunoreactive glial cells proliferate in most focal regions. We think: This suggests that in chronic epilepsy, glial cells synthesis, storage capacity of glutamic acid increased. Thus, even in the lesion area of nerve cells damaged, the number of cases reduced, still able to maintain a considerable pool of glutamate, and can be induced under certain factors, to the surrounding brain tissue, leading to the re-seizures. This study provides a possible neurochemical basis for recurrent episodes of chronic epilepsy.