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新药筛选,就是用动物实验来筛选、淘汰某种研制药物中药性评价结果不佳的候选成分。一般每10万个候选成分中只有2到3个可以成为最终成功上市的药物。以往新药筛选动物实验用得最多的是小白鼠,现在斑马鱼进入研究人员的视线,它是一种易于饲养的淡水热带鱼,是继老鼠、人类之后第三大脊椎类模式生物,其与人类基因同源性高达85%。传化集团孵化的环特生物公司专门研究斑马鱼药物筛选。浙江省“千人计划”专家、环特生物总裁李春启博士说,斑马鱼实验一周内就可完成,其成本只有老鼠实验的十分之一到百分之一。研发时间短、成本低使得斑马鱼被应用于抗癌类、心血管类和抗癫痫类等新药的筛选。
New drug screening, is to use animal experiments to screen, out of some of the drug development of traditional Chinese medicine evaluation of poor candidates. In general, only two to three out of every 100,000 candidates can be successful final marketed drugs. In the past, the most widely used animal drug for screening new animals was mouse. Nowadays, zebrafish have entered the sight of researchers. It is a kind of easy-to-feed freshwater tropical fish. It is the third largest spine-type organism after mouse and human, Homology up to 85%. Encyclopedia of the incubation group of special biotech company specializing in zebrafish drug screening. Zhejiang Province, “thousands of people plan” expert, Dr. Li Chunqi, president of the special ring, said the zebrafish experiment can be completed within a week, the cost of only one-tenth to one-hundredth of the mouse experiment. R & D time is short, low cost makes zebrafish is used in anti-cancer, cardiovascular and anti-epilepsy and other new drugs screening.