【摘 要】
：
Rhodium(III)-catalyzed coupling between ketoximes and alkynes via C–H activation and annulation typically followed the[4+2]selectivity to afford isoquinolines.
【机 构】
：
Dalian Institute of Chemical Physics, Chinese Academy of Sciences,
【出 处】
：
Science China(Chemistry)
论文部分内容阅读
Rhodium(III)-catalyzed coupling between ketoximes and alkynes via C–H activation and annulation typically followed the[4+2]selectivity to afford isoquinolines.By designing alkynes bearing a highly electron-withdrawing group and under substrate control,we have successfully switched the selectivity of the coupling between oximes and alkynes to the alternative[3+2]annulation,leading to the efficient synthesis of indenamines.This process features good regioselectivity for both substrates,high efficiency,broad substrate scope,and excellent functional group tolerance.
Rhodium (III) -catalyzed coupling between ketoximes and alkynes via C-H activation and annulation typically followed the [4 + 2] selectivity to afford isoquinolines. By designing alkynes bearing a highly electron-withdrawing group and under substrate control, we have successfully switched the selectivity of the coupling between oximes and alkynes to the alternative [3 + 2] annulation, leading to the efficient synthesis of indenamines. this process features good regioselectivity for both substrates, high efficiency, broad substrate scope, and excellent functional group tolerance.
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