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左旋多巴(L-多巴,下同)广泛地用于治疗人类的巴金森氏病,而且在离体条件下,还选择性地抑制人类黑色素瘤(Melanoma)色素细胞的生长。但除去对激素敏感的乳腺癌的特例之外,关于 L-多巴在体内的抗肿瘤活性至今尚缺乏证据。作者用实验性肿瘤系统(L1210淋巴细胞白血病,P388淋巴细胞白血病以及 B-16黑色素瘤)观察了L-多巴甲酯在体内的抗肿瘤作用。由于 L-多巴本身溶解度低,给小鼠注射的剂量不能超过每公斤体重
Levodopa (L-dopa, the same below) is widely used for the treatment of Parkinson’s disease in humans and also selectively inhibits the growth of human melanoma pigment cells under ex vivo conditions. However, in spite of the special cases of hormone-sensitive breast cancer, there is still no evidence on the antitumor activity of L-dopa in vivo. The authors used an experimental tumor system (L1210 lymphocytic leukemia, P388 lymphocytic leukemia and B-16 melanoma) to observe the antitumor effects of L-Dopa in vivo. Due to the low solubility of L-dopa itself, mice should not be given a dose of more than one kilogram of body weight