论文部分内容阅读
目的：研究人工合成的高活性钠素（hANP）对妊高征患者内源性心钠素（ANP）及内皮素（ET）分泌的影响，探讨hANP治疗妊高征的作用机制．方法：对16例妊高征患者应用hANP6μg／kg静点30min，用药前后各取肘静脉血，测血浆ANP，ET水平并监测血压变化及临床效果．随机对12例妊高征患者应用安慰剂治疗为对照组．结果：hANP治疗后血浆ANP显著增高（P＜0．01），ET呈下降趋势，但无统计学差异（P＞0．05），ANP／ET比值显著增高（P＜0．01）．平均动脉压（MAP）下降（2．30±1．02）kPa，MAP下降值与血浆ANP增高值呈显著正相关（P＜0．01），与ET下降值无显著相关性（P＞0．05）．用药后24h尿蛋白及水肿消退显著．对照组血浆ANP，ET，ANP／ET及MAP均无显著变化．结论：hANP诱导妊高征患者内源性ANP分泌，纠正ANP／ET平衡失调．其治疗妊高征的作用机制与调节内源性ANP，ET水平有关．
Objective: To investigate the effects of synthetic high activity sodium hANP on the secretion of endogenous atrial natriuretic peptide (ANP) and endothelin (ET) in patients with pregnancy induced hypertension (PIH) and to explore the mechanism of hANP in the treatment of PIH. Methods: 16 cases of PIH patients were treated with hANP 6μg / kg for 30 minutes. The elbow venous blood was taken before and after treatment. Plasma ANP and ET levels were measured and the blood pressure was monitored. Twelve patients with PIH were randomized to placebo for the control group. Results: After ANP treatment, plasma ANP was significantly increased (P <0.01), ET was decreased, but there was no significant difference (P> 0.05), ANP / ET ratio was significantly increased (P <0.01). MAP decreased (2.30 ± 1.02) kPa, MAP decreased positively correlated with plasma ANP increased (P <0.01), and had no significant correlation with ET decreased (P> 0 .05). Urine protein and edema disappeared significantly 24 hours after treatment. There was no significant change in plasma ANP, ET, ANP / ET and MAP in the control group. Conclusion: hANP induces endogenous ANP secretion in patients with PIH and corrects the imbalance of ANP / ET. The mechanism of its treatment of PIH is related to the regulation of endogenous ANP and ET levels.