目的：研究胰岛素溶液（ＩＮＳＳＯＬ）经正常大鼠肺部给药后的降血糖作用。方法：以血糖水平为指标，考察各种吸收促进剂以及酶抑制剂经正常大鼠肺部给药后对ＩＮＳＳＯＬ降血糖作用的影响。同时比较了ＩＮＳＳＯＬ在两种ｐＨ条件下的降血糖作用，并以皮下注射为对照，计算不同条件下ＩＮＳＳＯＬ的药理生物利用度（ｐｈａｒｍａｃｏｌｏｇｉｃａｌｂｉｏａｖａｉｌａｂｉｌｉｔｙ，ＰＢＡ）。结果：０５ｕ·ｋｇ－１的ＩＮＳＳＯＬ经肺部给药后即有明显的降血糖作用，在不加吸收促进剂的条件下的ＰＡ为２６０％。辛酸钠、胆酸钠、苄泽３５、苄泽７８和酶抑制剂杆菌肽均显著地增加ＩＮＳＳＯＬ的降血糖作用。ＩＮＳＳＯＬ在ｐＨ３时的降血糖效果比ｐＨ７时有显著的提高。结论：ＩＮＳＳＯＬ经肺部给药后有显著的降血糖效果。 Objective: To study the hypoglycemic effect of INS  SOL after pulmonary administration in normal rats. Methods: Based on the blood glucose level, the effects of various absorption enhancers and enzyme inhibitors on the hypoglycemic effect of INSSOL after pulmonary administration in normal rats were investigated. Simultaneously, the hypoglycemic effect of INSSOL at two pHs was compared and the pharmacological bioavailability (PBA) of INSSOL under different conditions was calculated by subcutaneous injection. Results: The 0.5 · · kg-1 INSOL had obvious hypoglycemic effect after pulmonary administration, and PA was 260% without absorption enhancer. Sodium caprylate, sodium cholate, Benzylperidol 35, Benzyl 78 and the enzyme inhibitor bacitracin significantly increased the hypoglycemic effect of INS-SOL. The hypoglycemic effect of INSSOL at pH3 was significantly higher than at pH7. CONCLUSIONS: There is a significant hypoglycemic effect after INS-SOL administration via the lungs.