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目的 :探讨Eph B4受体与其配体Ephrin B2在胃癌组织中的表达及其对血管生成和肿瘤生物学行为的影响。方法 :应用免疫组化SABC法检测 93例胃癌和 30例癌旁组织中Enp B4受体与其配体Ephrin B2的表达及间质微血管密度 (MVD)。结果 :胃癌组织中肿瘤细胞、间质新生血管的Eph B4与Ephrin B2高度表达 ,癌组织中Eph B4与Ephrin B2的阳性表达 (分别为 49.46 %和 50 .54 % )明显高于癌旁组织 (分别为 2 0 .0 %和 2 3 .3 % ,P <0 .0 1 )。Enp B4与Ephrin B2阳性表达组的平均MVD值 (分别为 56 .2 1± 1 5 .3和 62 .41± 1 6 .9)明显高于Enp B4与Ephrin B2阴性表达组 (分别为 32 .2 2± 1 2 .9和 34 .1 2± 1 4 .7,P <0 .0 5和P <0 .0 1 )。此外 ,Enp B4与Ephrin B2表达程度还与胃癌的转移和癌浸润程度密切相关。结论 :Enp B4与Ephrin B2可以促进肿瘤间质的血管生成 ,加速肿瘤浸润和转移
Objective: To investigate the expression of Eph B4 receptor and its ligand Ephrin B2 in gastric carcinoma and its effect on angiogenesis and tumor biological behavior. Methods: Immunohistochemical SABC method was used to detect the expression of Enp B4 receptor and its ligand Ephrin B2 and the density of mesenchymal microvessel (MVD) in 93 cases of gastric cancer and 30 cases of paracancerous tissues. Results: Eph B4 and Ephrin B2 were highly expressed in tumor cells and interstitial neovascularization in gastric cancer tissues. The positive expression of Eph B4 and Ephrin B2 in tumor tissues (49.46% and 50.54%, respectively) was significantly higher than that in paracancerous tissues Respectively 20.0% and 23.3%, P <0.01). The average MVD values of Enp B4 and Ephrin B2 positive groups (56.21 ± 13.5 and 62.41 ± 1.6.9, respectively) were significantly higher than those of Enp B4 and Ephrin B2 negative groups (32 and 32, respectively). 2 2 ± 1 2 .9 and 34 .1 2 ± 14.7, P <0.05 and P <0.01). In addition, the expression of Enp B4 and Ephrin B2 is also closely related to the metastasis of gastric cancer and the degree of cancer invasion. Conclusion: Enp B4 and Ephrin B2 can promote angiogenesis of tumor interstitium and accelerate tumor invasion and metastasis