C3肾小球病的历史由来:溯源1974年,Verroust等在一组肾脏疾病患者肾组织免疫荧光检查中发现,肾小球仅见C3沉积,免疫球蛋白和C1q阴性。研究者们认为这可能是一类新的肾小球病,但对其的命名一直未能统一,而且发病机制并不清楚。之后,人们逐渐发现其发病与补体旁路途径调节异常可能相关。后来又发现部分Ⅰ型膜增生性肾小球肾炎(MPGN)患者的肾小球免疫荧光显示仅C3沉 History of C3 glomerulopathy: traceability In 1974, Verroust et al found in a group of kidney disease patients with renal tissue immunofluorescence that only glomerular C3 deposition, immunoglobulin and C1q negative. Researchers think this may be a new class of glomerular disease, but its naming has not been uniform, and the pathogenesis is not clear. Later, people gradually found that the pathogenesis of complement bypass pathway may be related to abnormal regulation. Later, it was found that glomerular immunofluorescence in some patients with type I membranoproliferative glomerulonephritis (MPGN) showed only C3