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目的:评价在肾移植急性血管性排斥反应诊断中用间接免疫荧光法(IF)检测血清抗中性粒细胞胞浆抗体(ANCA)和ELISA法检测血清抗髓过氧化物酶抗体(MPO-ANCA)同步检测的意义。方法:回顾性总结了41例经肾活检确诊的肾移植排斥反应患者ANCA的检出率,了解AN-CA阳性的肾移植排斥反应的种类及其临床病理特点。结果:141例肾移植患者有11例血清IF-ANCA阳性,有15例血清MPO-ANCA阳性。2IF-ANAC和MPO-ANCA同时阳性主要见于肾移植急性血管性排斥反应。结论:血清MPO-ANCA和IF-ANCA同步检测可以提高对肾移植急性血管性排斥反应诊断价值。
Objective: To evaluate the diagnostic value of serum anti-neutrophil cytoplasmic antibody (ANCA) by indirect immunofluorescence assay (IF) and serum anti-myeloperoxidase antibody (MPO-ANCA) in the diagnosis of acute vascular rejection after renal transplantation ) Synchronous detection of the meaning. Methods: The clinical data of ANCA in 41 renal transplant recipients diagnosed by renal biopsy were retrospectively reviewed. The types and clinical and pathological features of AN-CA positive renal allograft rejection were analyzed. Results: Serum IF-ANCA was positive in 11 of 141 kidney transplant patients and 15 MPO-ANCA-positive in serum. The concurrent positive findings of 2IF-ANAC and MPO-ANCA were mainly found in acute vascular rejection of renal allografts. Conclusion: Simultaneous detection of serum MPO-ANCA and IF-ANCA can improve the diagnostic value of acute vascular rejection in renal transplantation.