Objective: To observe the therapeutic effect of compound decoction of Comcide (CDC), a traditional Chinese medicine (TCM) in treating the withdrawal reaction (WR) of heroin dependent rhesuses (HDR). Methods: To study therapeutic effects of CDC and methadone in treating WR of HDR models induced by administering of heroin. Through observing, comparing and evaluating the scores of all groups gained during the first 4 days when the WR was most severe. Results: CDC and methadone had the same therapeutic effects on WR of HDR. There were significant differences between the scores of CDC and methadone, and that of natural withdrawal, P<0.01; while there were insignificant difference between the scores of CDC and that of methadone, P>0.05. Conclusion: CDC had the therapeutic effect in treating WR of HDR. Objective: To observe the therapeutic effect of compound decoction of Comcide (CDC), a traditional Chinese medicine (TCM) in treating the withdrawal reaction (WR) of heroin dependent rhesuses (HDR). Methods: To study therapeutic effects of CDC and methadone in Treated WR of HDR models induced by administering of heroin. Through observing, comparing and evaluating the scores of all groups yield during the first 4 days when the WR was most severe. Results: CDC and methadone had the same therapeutic effects on WR of HDR. There were significant differences between the scores of CDC and methadone, and that of natural withdrawal, P<0.01; while there were insignificant difference between the scores of CDC and that of methadone, P>0.05. Conclusion: CDC had the therapeutic effect in treating. WR of HDR.