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本文对１０５例糖尿病患者尿中Ｎ－乙酰－β－Ｄ氨基葡萄糖苷酶（ＮＡＧ）、白蛋白（Ａｌｂ）、β２－微球蛋白（β２－ＭＧ）及尿糖进行了检测，结果显示：（１）尿ＮＡＧ和尿Ａｌｂ的检测相比，对早期糖尿病肾病的诊断有相似的敏感性，在早期ＤＮ患者中，尿ＮＡＧ活性与尿Ａｌｂ排泄呈显著正相关，但在临床ＤＮ患者中，尿ＮＡＧ活性与尿Ａｌｂ无相关性；（２）不论尿β２－ＭＧ正常或增高的患者中，尿ＮＡＧ活性与尿β２－ＭＧ排泄量均无相关性；（３）在２４小时尿糖＜５９、５～１５ｇ及＞１５ｇ的三组患老中，尿ＮＡＧ与２４小时尿糖排泄量亦均无相关性。本文研究提示：测定糖尿病患者尿ＮＡＧ活性可作为一筛选早期ＤＮ的一敏感指标，尿ＮＡＧ活性与尿β２－ＭＧ及尿糖排泄量无直接关系。
In this paper, 105 cases of diabetic patients with urine N-acetyl-β-D glucosaminidase (NAG), albumin (Alb), β2-microglobulin (β2-MG) and urine sugar were detected, the results showed: 1) Compared with the detection of urinary Alb, urinary NAG has similar sensitivity to the diagnosis of early diabetic nephropathy. In early DN patients, urinary NAG activity is positively correlated with urine Alb excretion, but in clinical DN patients, urine NAG activity had no correlation with urine Alb. (2) No correlation was found between urinary NAG activity and urinary β2-MG excretion in patients with normal or elevated urinary β2-MG levels. (3) 5 ~ 15g and> 15g of three groups of elderly, urinary NAG and 24-hour urinary glucose excretion also had no correlation. This study suggests that: Determination of urinary NAG activity in diabetic patients can be used as a sensitive screening index of early DN, urinary NAG activity and urinary β2-MG and urinary glucose excretion is not directly related.