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消化性溃疡是全球性的常见病和多发病.其治疗以饮食疗法和抗酸剂、抗胆碱能药物以及h_2受体阻滞剂等为主.传统的以阿托品为代表的抗胆碱能药物因抗溃疡疗效差.副作用多而未能广泛应用.哌仑西平(江苏盐城制药厂提供)一方面作为新型抗胆碱能药,能选择性地阻滞壁细胞上M受体,而对其它组织和器官上M受体亲和力低.故治疗剂量很少有其它抗胆碱能药物的副作用出现.该药保留了传统抗胆碱能药物的优点、去掉了其缺点;另一方面,它能促进胃粘液的合成和分泌,能增强;胃膜屏障,促进溃疡愈合;是一种较有前途的抗清病药.雷尼技替作为H_2受体阻滞剂.对治疗消化性溃疡有肯定疗效.其作用主要是阻滞壁细胞上的H_2受体来抑制胃酸的分泌.虽然哌仑西平和雷尼替丁都抑制胃酸分泌,但作用机理不同.本文旨在探讨二者合用时对十二指肠球都溃疡的疗效.
Peptic ulcer is a common and frequently-occurring disease in the world, and its treatment is based on diet therapy and antacids, anticholinergic drugs and h_2 receptor blockers, etc. The traditional anticholinergic drugs represented by atropine Because of anti-ulcer efficacy is poor. Side effects and more than can not be widely used. Pirenzepine (Jiangsu Yancheng Pharmaceutical Factory) on the one hand as a new type of anticholinergic drugs, can selectively block M cells on parietal cells, while other Tissue and organ M receptor affinity is low, so the treatment dose is rarely the side effects of other anticholinergic drugs. The medicine retains the advantages of traditional anticholinergic drugs, remove the shortcomings; the other hand, it can Promote gastric mucus synthesis and secretion, can enhance; gastric barrier, promote ulcer healing; is a more promising anti-Qing medicine .Renyi technology as a H_2 receptor blocker.For the treatment of peptic ulcer have affirmed Its main role is to block the cell wall H_2 receptor to inhibit gastric acid secretion.Although both pirenzepine and ranitidine inhibit gastric acid secretion, but the mechanism of action is different.This paper aims to explore the combination of the two when the ten Duodenal ulcer effect.