甲_2巨球蛋白(α_2M)制剂,配合手术治疗或单独应用治疗放射性皮肤粘膜损伤已十余年,疗效满意。α_2M为广谱蛋白酶抑制剂,可调节细胞内外蛋白酶水平。Burger等报道,全身照射小鼠给予α_2M治疗,可促进骨髓造血与胸腺再生,提高了小鼠的存活率。Hoffman等体外实验,观察到α_2M与蛋白酶结合,有抑制粒细胞超氧阴离子自由基释放的作用。α_2M在大鼠为急性相蛋白,结构与人α_2M类似。我等用~(60)钴源致死剂量照射Wistar大鼠。观察照后一周内大鼠体 A _2 macroglobulin (α_2M) preparations, with surgical treatment or single application of radioactive skin and mucosal injury has been more than 10 years, with satisfactory results. α_2M is a broad-spectrum protease inhibitor, which can regulate intracellular and extracellular protease levels. Burger et al reported that systemic irradiation of mice given α_2M treatment can promote bone marrow hematopoiesis and thymus regeneration and improve the survival rate of mice. Hoffman and other in vitro experiments, α 2 M was observed and protease binding, inhibit granulocyte superoxide anion free radical release. α_2M is an acute phase protein in rats with a similar structure to human α_2M. I use other ~ (60) cobalt lethal dose irradiation Wistar rats. Observed after a week of rat body