目的：对１４０例肝病患者血清进行联合检测。方法：用放免法分组联合检测肝病患者血清甘胆酸（ＣＧ）、透明质酸（ＨＡ）、层粘素（ＬＮ）、β２微球蛋白（β２ＭＧ）和铁蛋白（Ｆｅ）值。结果：ＣＧ和β２ＭＧ在ＬＣ组比其它各组差异有显著性（Ｐ＜０．０５）；ＨＡ和ＬＮ在ＣＡＨ、ＬＣ和ＨＣＣ组比其它各组差异有显著性（Ｐ＜０．０５）；ＨＡ和ＬＮ在ＣＡＨ、ＬＣ和ＨＣＣ组比其它各组差异有显著性（Ｐ＜０．０５）；Ｆｅ在ＨＣＣ组比其它各组差异有显著性（Ｐ＜０．０５）。结论：该方法对肝病的早期诊断、预后和鉴别诊断有重要的临床意义 Objective: To detect the serum of 140 patients with liver disease. Methods: Serum levels of glycocholate (CG), hyaluronic acid (HA), laminin (LN), β2microglobulin (β2MG) and ferritin (Fe) were determined by radioimmunoassay in patients with liver disease. Results: The differences of CG and β2MG between LC group and other groups were significant (P <0.05). HA and LN in CAH, LC and HCC groups were significantly different from other groups (P <0.05 ). HA and LN in CAH, LC and HCC groups were significantly different from other groups (P <0.05). Fe in HCC group was significantly different from other groups (P <0.05). Conclusion: This method has important clinical significance for the early diagnosis, prognosis and differential diagnosis of liver disease