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目的 探讨哮喘患儿血清嗜酸细胞阳离子蛋白 (ECP)、总IgE(T -IgE)和外周血嗜酸细胞 (PBEC)的变化及临床意义。方法 采用荧光酶联免疫法测定 77例哮喘患儿血清ECP、T -IgE水平 ,同时进行PBEC计数和呼气峰流速 (PEFR)测定 (5岁以上 )。结果 哮喘患儿发作期ECP、T -IgE水平及PBEC计数明显升高 ;缓解期ECP水平降至正常 ,T -IgE水平及PBEC计数虽然明显下降 ,但仍高于对照组 ;发作期ECP水平与PEFR占预计值的百分比 (PEFR % )呈显著负相关 ,T -IgE水平与PBEC计数呈显著正相关。 结论 PBEC和T -IgE水平升高是哮喘发病的重要因素 ,ECP水平可反映哮喘炎症的严重程度
Objective To investigate the changes and clinical significance of serum eosinophil cationic protein (ECP), total IgE (T-IgE) and peripheral blood eosinophil (PBEC) in children with asthma. Methods Serum levels of ECP and T-IgE in 77 asthmatic children were measured by fluorescence enzyme-linked immunosorbent assay (ELISA). PBEC count and peak expiratory flow (PEFR) were measured simultaneously (over 5 years old). Results The levels of ECP, T-IgE and PBEC in children with asthma were significantly increased during the attack period. The levels of ECP in the remission period were reduced to normal. The levels of T-IgE and PBEC were significantly lower than those of the control group There was a significant negative correlation between PEFR and the percentage of predicted value (PEFR%), and there was a significant positive correlation between T-IgE level and PBEC count. Conclusion The elevated levels of PBEC and T-IgE are important factors in the pathogenesis of asthma. The level of ECP may reflect the severity of asthma inflammation