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用ＤＧＤ包埋超薄切片的电镜观察表明，北京鸭腔上囊淋巴细胞的分化过程中，中间纤维－核纤层－核内骨架体系变化明显。淋巴母细胞的中间纤维呈致密的网络状，核纤层较薄，核内骨架纤维网络稀疏。中淋巴细胞和小淋巴细胞的中间纤维网络变得稀疏，核纤层增厚，核内骨架呈现致密的纤维网络状结构，其上附着许多颗粒样物质，抗波形蛋白抗体和抗核纤层蛋白抗体的间接免疫荧光染色同样表明，淋巴母细胞胞质的波形纤维呈网络状，核纤层呈弱阳性反应；中淋巴细胞和小淋巴细胞的胞质波形纤维网络结构不明显，核纤层则呈强阳性反应。结果提示，淋巴细胞中间纤维－核纤层－核内骨架体系的变化与淋巴细胞增殖和分化过程密切相关。
Electron microscopic observation of DGD-embedded ultra-thin sections showed that there was a significant change in the central fibro-nuclear lamina-endoskeleton system during the differentiation of the duck bursal epithelial lymphocytes in Beijing. The intermediate fibers of lymphoblasts showed a dense network, thin nuclear layer, sparse nuclear fiber network. Intermediate lymphocytes and small lymphocytes in the middle of the network becomes thinning, thickening of the nuclear layer, the nuclear skeleton showed a dense fibrous network structure, which attached to the many particulate matter, anti-vimentin antibody and anti-lamin layer protein Indirect immunofluorescence staining of antibodies also showed that the cytoplasm of lymphoblasts showed a network of fibrous fibers with a weakly positive nuclear lamina. The cytoplasmic fibrous structures of lymphocytes and small lymphocytes were not obvious, Was strongly positive reaction. The results suggest that the changes of lymphocyte intermediate fiber - nuclear lamina - nucleus skeleton system are closely related to the process of lymphocyte proliferation and differentiation.