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目的:探讨富氧水对高原人体运动后自由基代谢的影响。方法:在海拔3700m选择10名已习服半年的健康男性青年,在海拔5380m选择10名已习服2个月的男性青年,均采用口服富氧水前(对照组)后(实验组)的自身对比运动负荷双盲实验。实验组口服富氧水,对照组口服5%葡萄糖注射液,每次500mL,一日2次,连续服用3天。运动结束后检测血中超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)及其合酶(NOS)在口服富氧水前后的变化。结果:海拔3700m和5380m负荷运动后,实验组SOD、NO和NOS增高,差别有非常显著性(P<0.01);MDA降低,差别有显著性(P<0.05或0.01)。结论:富氧水可增加体内氧含量,对低氧造成的自由基代谢失衡有调节作用。
Objective: To investigate the effect of oxygen-enriched water on free radical metabolism after high altitude exercise. METHODS: Ten healthy male youths who had served for half a year at 3700 m above sea level were enrolled in this study. Ten male adolescents who had been served for 2 months at 5380 m above sea level were selected before oral administration of oxygen-enriched water (control group) Self-contrast double-blind exercise load test. The experimental group orally oxygenated water, the control group oral 5% glucose injection, each 500mL, 2 times a day for 3 consecutive days. Changes of blood superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO) and its synthase (NOS) before and after oral administration of oxygen-enriched water were measured after exercise. Results: The activities of SOD, NO and NOS in the experimental group increased after 3700m and 5380m load exercise, the difference was significant (P <0.01); MDA decreased, the difference was significant (P <0.05 or 0.01). Conclusion: Oxygen-enriched water can increase the oxygen content in the body and regulate the imbalance of free radical metabolism caused by hypoxia.