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目的探讨辅助生殖技术(ART)助孕妊娠后发生自然减胎(SPR)发生的相关因素和对妊娠结局的影响。方法回顾性分析2003年1月-2008年12月我院ART术后妊娠的3506例患者,分析与SPR有关的因素和妊娠结局。结果 ART后SPR的发生与移植的胚胎质量有关;发生SPR后出生低体重儿和早产的可能性增大;SPR发生越晚,其产科异常结局风险越大。结论选择优质胚胎的单胚胎移植(SET),可能是有效避免多胎妊娠,减少SPR发生的根本之举。此外,在对多胎妊娠实行选择性减胎时应充分考虑SPR的发生时间及发生率。
Objective To investigate the related factors of spontaneous embryogenesis (SPR) after pregnancy assisted by assisted reproductive technology (ART) and its effect on pregnancy outcomes. Methods A retrospective analysis of 3506 patients with post-ART ART in our hospital from January 2003 to December 2008 was conducted to analyze the factors related to SPR and the outcome of pregnancy. Results The incidence of SPR in ART was related to the quality of embryos transferred. The possibility of low birth weight infants and premature birth increased after SPR. The later the SPR occurred, the higher the risk of obstetric abnormalities. Conclusions Single embryo transfer (SET) with high quality embryo selection may be the fundamental way to avoid multiple pregnancy and reduce the occurrence of SPR. In addition, in the selective pregnancy reduction of multiple pregnancies should take full account of the occurrence of SPR and incidence.