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目的 探讨慢性肾功能衰竭患者血、尿中血管内皮生长因子 (VEGF)的作用及其临床意义。方法 采用ELISA方法测定 31例慢性肾功能衰竭患者 (其中失代偿期患者 15例 ,肾功能衰竭期患者 16例 )和 15例正常人的血、尿中的VEGF水平。结果 不同阶段慢性肾功能衰竭患者血、尿液中的VEGF水平均明显高于对照组P<0 .0 0 1,P <0 .0 1。在肾功能衰竭期 ,血、尿液中的VEGF水平高于失代偿期P <0 .0 1,P <0 .0 0 1。尿液中的VEGF与肾小球滤过率 (GFR)呈负相关 ,与血肌酐 (Scr)和尿素氮 (BUN)呈正相关。结论 慢性肾功能衰竭患者血、尿液中的VEGF水平增高 ,可能与肾小球毛细血管损伤的修复增强 ,保护和维持肾功能有关。肾功能的损害越重 ,尿液中的VEGF排泌越多 ,VEGF可作为反映肾功能的一个独特标志。
Objective To investigate the role of vascular endothelial growth factor (VEGF) in blood and urine of patients with chronic renal failure and its clinical significance. Methods The levels of VEGF in serum and urine of 31 patients with chronic renal failure (including 15 decompensated patients and 16 patients with renal failure) and 15 normal controls were measured by ELISA. Results The levels of VEGF in blood and urine of patients with chronic renal failure in different stages were significantly higher than those in control group (P <0.01, P <0.01). In renal failure, VEGF levels in blood and urine were higher than those in decompensated P <0.01, P <0.001. Urinary VEGF and glomerular filtration rate (GFR) was negatively correlated with serum creatinine (Scr) and urea nitrogen (BUN) was positively correlated. Conclusion The levels of VEGF in blood and urine increased in patients with chronic renal failure, which may be related to the enhancement of glomerular capillary damage and the protection and maintenance of renal function. The more severe the impairment of renal function, the more VEGF excretion in the urine. VEGF can be used as a unique marker of renal function.