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胃粘膜的肠腺上皮化生早在1883年便由Kupffer首先描述,至1896年Shmidt发现这种病变常和慢性胃炎合并存在。近几十年来,许多人研究了此种病变与胃癌的相互关系,有认为系一种恶性前期病变。定义所谓肠腺上皮化生(简称肠腺化生)系指胃粘膜内有肠腺上皮存在,轻者仅有少数肠上皮细胞存在,重者甚至可见到肠绒毛形成。Morson认为,肠腺化生最突出的特征,也是与正常胃粘膜的重要区别在于杯状细胞的出现。这些细胞中的粘液在组织化学上与胃粘液不同。此外,在正常肠上皮内可见到的各种细
Epithelial metaplasia of the gastric mucosa was first described by Kupffer in 1883. By 1896, Shmidt found that this disease was often associated with chronic gastritis. In recent decades, many people have studied the relationship between this type of lesion and gastric cancer, and it is considered to be a premalignant lesion. The definition of the so-called intestinal gland metaplasia (abbreviated gland metaplasia) refers to the presence of intestinal gland epithelium in the gastric mucosa, light only a small number of intestinal epithelial cells exist, even severe intestinal villus can be seen. Morson believes that the most prominent feature of intestinal metaplasia is also an important difference from the normal gastric mucosa is the appearance of goblet cells. The mucus in these cells is histochemically different from gastric mucus. In addition, various fine details can be seen in normal intestinal epithelium.