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观察天荔汤对四氧嘧啶糖尿病大鼠早期肾脏病变及相关状况的影响。结果表明:高剂量天荔汤可明显降低糖尿病血糖,改善症状,显著抑制糖尿病早期的肾脏肥大、肾小球高滤过和蛋白尿,并抑制其升高的血浆肾素活性(PRA)、血管紧张素Ⅱ(ATⅡ)水平。此外,天荔汤还可降低糖尿病血清胆固醇和甘油三酯水平。提示天荔汤可有效地防止糖尿病早期肾脏病变的发生、发展,其机理与天荔汤能控制血糖、改善肾血流动力学、影响肾素-血管紧张素系统和纠正脂代谢紊乱等有关
Observe the effect of Tianqi Decoction on early renal lesions and related status of alloxan-induced diabetic rats. The results showed that: high-dose Tianzhu Decoction can significantly reduce blood glucose, improve symptoms, significantly inhibit early renal hypertrophy, glomerular hyperfiltration and proteinuria, and inhibit its elevated plasma renin activity (PRA), blood vessels ATII levels. In addition, Scorpio Decoction can reduce serum cholesterol and triglyceride levels in diabetes. Tips Tianqi Decoction can effectively prevent the occurrence and development of early renal pathological changes in diabetes, and its mechanism is related to the control of blood stasis, improvement of renal hemodynamics, influence of renin-angiotensin system and correction of lipid metabolism disorders.