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目的:探讨盐酸特布他林注射液治疗小儿喘息性支气管炎的临床疗效及安全性。方法:喘息性支气管炎患儿122例随机分成对照组60例和观察组62例。在常规治疗基础上,对照组加用氨茶碱注射液ivd qd;观察组加用盐酸特布他林注射液ivd qd。均7 d为一个疗程。比较两组患儿临床疗效、治疗前后肺功能各项指标变化及药品不良反应。结果:观察组总有效率为91.93%,明显高于对照组的63.33%(P<0.05)。观察组治疗后咳嗽、喘憋、肺部啰音消失时间及住院时间均显著短于对照组(P<0.05),肺功能改善也显著优于对照组(P<0.05)。对照组发生不良反应17例,高于观察组的7例(P<0.05)。结论:盐酸特布他林注射液治疗小儿喘息性支气管炎效果显著,可有效改善患儿临床症状及肺功能,缩短住院时间,且不良反应少。
Objective: To investigate the clinical efficacy and safety of Terbutaline Hydrochloride Injection in children with asthmatic bronchitis. Methods: 122 children with asthmatic bronchitis were randomly divided into control group (60 cases) and observation group (62 cases). On the basis of routine treatment, the control group plus aminophylline injection ivd qd; observation group plus terbutaline hydrochloride injection ivd qd. 7 d for a course of treatment. The clinical curative effect of two groups of children was compared, the indexes of pulmonary function before and after treatment were changed, and the side effects of drugs were analyzed. Results: The total effective rate in the observation group was 91.93%, which was significantly higher than that in the control group (63.33%, P <0.05). The cough, wheezing, disappearance of pulmonary rales and hospital stay in the observation group were significantly shorter than those in the control group (P <0.05), and pulmonary function improvement was also significantly better than the control group (P <0.05). There were 17 adverse reactions in the control group, which were higher than those in the observation group (P <0.05). Conclusion: Terbutaline hydrochloride injection is effective in treating infantile asthmatic bronchitis, which can effectively improve the clinical symptoms and pulmonary function of children, shorten the length of hospital stay and have fewer adverse reactions.