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先前研究证实,口服单剂脂质包裹的卡介苗(BCG)能保护BALB/c小鼠免受牛型分枝杆菌83/6325株气溶胶攻击,此项研究旨在进一步评价小鼠口服该脂质包裹的BCG能否抵抗有毒力人结核杆菌H37Rv气溶胶攻击。将处于对数生长中期的BCG包裹于脂质C或脂质K制成两种不同配方的脂质包裹的BCG。?
Previous studies demonstrated that oral administration of a single dose of lipid-coated BCG protects BALB / c mice from challenge with M. bovis 83/6325 aerosol, a study to further evaluate the efficacy of oral administration of the lipid Wrapped BCG Can Resist Virulent Mycobacterium Tuberculosis H37Rv Aerosol Attack. BCG in mid-logarithmic growth phase was coated on lipid C or lipid K to make two different formulations of lipid-coated BCG. ?