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过氧化物酶体增殖物活化受体(peroxisome proliferators activated receptors,PPARs)属于激素核受体超家族,是一类可以被过氧化物酶体增殖物(peroxisome proliferator,PP)激活的核转录因子。PPAR存在3种亚型:PPARα、PPARβ、PPARγ。其中PPARγ参与肝星状细胞(HSC)的活化,与细胞因子共同调控HSC的增殖及细胞外基质(ECM)的生成。研究表明,肝损伤过程中炎症介质的释放和纤维化的进展与PPARγ的表达量减少和功能异常有关[1],故提高PPARγ的表达可能抑制
Peroxisome proliferators activated receptors (PPARs) belong to the nuclear hormone receptor superfamily and belong to a class of nuclear transcription factors that can be activated by peroxisome proliferator (PP). There are three subtypes of PPAR: PPARα, PPARβ, PPARγ. Among them, PPARγ is involved in the activation of hepatic stellate cells (HSCs), which together with cytokines regulate the proliferation of HSCs and the production of extracellular matrix (ECM). Studies have shown that the release of inflammatory mediators and the progression of fibrosis during liver injury are related to the decreased expression and dysfunction of PPARγ [1], so increasing PPARγ expression may inhibit