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目的探讨血腑逐瘀汤辅助治疗子宫肌瘤对患者黄体生成素(LH)、雌二醇(E_2)、卵泡刺激素(FSH)水平的影响及安全性分析,比较治疗前后子宫体积、子宫肌瘤体积、月经周期、月经量、LH、E_2、FSH水平的变化,并比较临床疗效及不良反应。方法选择2013年1月-2016年7月该院收治的100例子宫肌瘤患者作为研究对象,按照随机数字表法分为观察组(50例)和对照组(50例)。对照组在月经结束后第1天,口服米非司酮进行治疗;观察组在对照组基础上联合血腑逐瘀汤治疗,两组均连续治疗3个月。结果治疗后,两组患者子宫体积、子宫肌瘤体积、月经周期、月经量、LH、E_2、FSH均显著改善,和治疗前比较差异有统计学意义(P<0.05);观察组子宫体积、子宫肌瘤体积均明显小于对照组(P<0.05),月经周期短于对照组,月经量少于对照组(P<0.05),LH、E_2、FSH水平比对照组低(P<0.05),临床总有效率明显高于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论对于子宫肌瘤患者采用血腑逐瘀汤辅助治疗效果显著,可有效降低LH、E_2、FSH水平表达,缩小肌瘤体积,安全性高。
Objective To investigate the effect and safety of Fufuzhuyutang adjuvant treatment of uterine fibroids on patients with luteinizing hormone (LH), estradiol (E_2) and follicle-stimulating hormone (FSH) and compare the uterine volume, uterine muscle Tumor volume, menstrual cycle, menstrual flow, LH, E_2, FSH levels, and compare the clinical efficacy and adverse reactions. Methods From January 2013 to July 2016, 100 patients with uterine fibroids admitted to our hospital were enrolled and divided into observation group (50 cases) and control group (50 cases) according to random number table. The control group was treated with mifepristone on the first day after the end of menstruation. The observation group was treated on the basis of the control group with Xuefuzhuyu Decoction, and the two groups were treated continuously for 3 months. Results After treatment, uterine fibroids volume, uterine fibroids volume, menstrual cycle, menstrual flow, LH, E_2 and FSH were significantly improved in both groups, with statistical significance (P <0.05) The volume of uterine leiomyoma was significantly lower than that of the control group (P <0.05), menstrual cycle was shorter than that of the control group, menstruation was less than the control group (P <0.05) The total clinical effective rate was significantly higher than that of the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The treatment of uterine leiomyoma with Fufuzhuyu decoction is effective and can effectively reduce the expression of LH, E_2 and FSH, reduce the size of fibroids, and has high safety.