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最近日本京都大学医学院 Numa 实验室丛家兔骨骼肌纯化了钙通道阻断剂二氢嘧啶(dihydropyridine,DHP)的受体,并利用重组 DNA 技术推出其一级结构。比较 DHP 受体、Na~+通道和 K~+通道及由此预测的二级结构,发现三者具有十分相似的共同特征,提示 DHP 受体就是骨骼肌细胞膜上起兴奋收缩偶联作用的电压感受器和 Ca~(2+)通道。因此,Na~+、K~+、Ca~(2+)这三种通道构成由一个祖先基因进化而来的电压门控通道家族。
Recently, Numa Laboratory, Kyoto University School of Medicine, Japan, purified the receptor of calcium channel blocker dihydropyridine (DHP) from rabbit muscle and introduced its primary structure by recombinant DNA technology. Comparison of DHP receptor, Na ~ + channel and K ~ + channel and the predicted secondary structure, found that the three have very similar common features, suggesting that the DHP receptor is the excitation and contraction of skeletal muscle cell membrane coupling voltage Receptors and Ca ~ (2+) channels. Therefore, the three channels of Na ~ +, K ~ +, and Ca ~ (2+) constitute a family of voltage-gated channels evolved from one ancestral gene.