【摘 要】
：
Metformin (MET),an antidiabetic agent,also has antioxidative effects in metabolic-related hypertension.This study was designed to determine whether MET has anti-hypertensive effects in salt-sensitive hypertensive rats by inhibiting oxidative stress in the
【机 构】
：
Department of Physiology and Pathophysiology, Xi’an Jiaotong University School of Basic Medical Scie
论文部分内容阅读
Metformin (MET),an antidiabetic agent,also has antioxidative effects in metabolic-related hypertension.This study was designed to determine whether MET has anti-hypertensive effects in salt-sensitive hypertensive rats by inhibiting oxidative stress in the hypothalamic paraventricular nucleus (PVN).Salt-sensitive rats received a high-salt (HS) diet to induce hypertension,or a normal-salt (NS) diet as control.At the same time,they received intracerebroventricular (ICV) infusion of MET or vehicle for 6 weeks.We found that HS rats had higher oxidative stress levels and mean arterial pressure (MAP) than NS rats.ICV infusion of MET attenuated MAP and reduced plasma norepinephrine levels in HS rats.It also decreased reactive oxygen species and the expression of subunits of NAD(P)H oxidase,improved the superoxide dismutase activity,reduced components of the renin-angiotensin system,and altered neurotransmitters in the PVN.Our findings suggest that central MET administration lowers MAP in saltsensitive hypertension via attenuating oxidative stress,inhibiting the renin-angiotensin system,and restoring the balance between excitatory and inhibitory neurotransmitters in the PVN.
其他文献
In this study,the distribution of five Alzheimer\'s disease (AD)-related single nucleotide polymorphisms (SNPs) in the Han population was examined in combination with the evaluation of clinical cognition and brain pathological analysis.The associations
Huntington\'s disease (HD) is a deadly neurodegenerative disease with abnormal expansion of CAG repeats in the huntingtin gene.Mutant Huntingtin protein (mHTT) forms abnormal aggregates and intranuclear inclusions in specific neurons,resulting in cell d
Bipolar disorder (BD) is a chronic,recurrent,disabling disease,even when given currently-available pharmacological and psychological treatments.Currently,the etiology and pathogenesis of BD remain unclear.
Identifying data-driven biotypes of major depressive disorder (MDD) has promise for the clarification of diagnostic heterogeneity.However,few studies have focused on white-matter abnormalities for MDD subtyping.This study included 116 patients with MDD an
Alzheimer\'s disease (AD) is the most common neurode-generative disease that affects memory,thinking,behavior,and the ability to perform everyday activities.It has been estimated that more than 35 million people worldwide suffered from AD in 2018 [1],an
Intermedin/adrenomedullin-2 (IMD/AM2),a member of the calcitonin gene-related peptide/AM family,plays an important role in protecting the cardiovascular system.However,its role in the enhanced sympathoexcitation in obesity-related hypertension is unknown.
GGGGCC repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FrD).It has been reported that hexanucleotide repeat expansions in C9ORF72 produce five dipeptide repeat (DPR) prote
Synaptic dysfunction and abnormal processing of amyloid precursor protein (APP) are early pathological features in Alzheimer\'s disease (AD).Recently,noncoding RNAs such as microRNAs (miRNAs) and circular RNAs (circRNAs) have been reported to contribute
Gastrodin is a phenolic glycoside that has been demonstrated to provide neuroprotection in preclinical models of central nervous system disease,but its effect in subarachnoid hemorrhage (SAH) remains unclear.In this study,we showed that intraperitoneal ad
Leukemia inhibitory factor (LIF) contributes to the neuroprotection by neural stem cells (NSCs) after ischemic stroke.Our aim was to explore whether LIF-transfected NSCs (LIF-NSCs) can ameliorate brain injury and promote neuroprotection in a rat model of