本文比较丙氟哌酸单次及多次给药后的药代动力学以及组织穿透性。选取正常青年志愿者12人(6女6男)。试验第一日予单剂500mg以饮水200ml空腹服用。第二日起每8小时服500mg直至第六日晨。于试验第1、3、6日分别留取不同时间的血、水疱液、唾液和尿标本。应用负压吸收 This article compares the pharmacokinetics and tissue penetration of propofol with single and multiple doses. 12 normal young volunteers were selected (6 female and 6 male). The first day of test to a single dose of 500mg drinking 200ml fasting take. From the second day every 500 hours until the sixth morning 500mg. Blood, blister fluid, saliva and urine samples were collected on days 1, 3 and 6 of the experiment respectively. Application of negative pressure absorption