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目的探讨胃印戒细胞癌(SRC)的临床病理特征。方法回顾性分析68例胃SRC和518例非印戒细胞癌(NSRC)的临床病理特点。结果 SRC女性发病率为44.1%,明显高于NSRC的27.2%(P<0.05);SRC胃下部发生率为60.3%,明显高于NSRC的43.8%(P<0.05);SRC易浸润黏膜层或黏膜下层,突破肌层者少于NSRC(P<0.05);SRC易形成脉管癌栓。而在年龄、淋巴结转移、神经侵犯等方面两者差异无统计学意义。结论胃SRC好发于女性,胃下部多见,易在胃壁内呈弥漫性生长和形成脉管内癌栓。
Objective To investigate the clinicopathological features of gastric signet ring cell carcinoma (SRC). Methods The clinical and pathological features of 68 cases of gastric SRC and 518 cases of non-signet ring cell carcinoma (NSRC) were retrospectively analyzed. Results The incidence of SRC in women was 44.1%, which was significantly higher than that in NSRC (27.2%, P <0.05). The incidence of gastric lower in SRC was 60.3%, significantly higher than that in NSRC (43.8%) (P <0.05) Submucosa, muscle break less than NSRC (P <0.05); SRC easy to form vascular thrombosis. There was no significant difference between the two groups in age, lymph node metastasis and nerve invasion. Conclusion Stomach SRC is more common in women than in the lower part of the stomach. It is easy to grow diffusely in the stomach wall and form an intravascular tumor thrombus.