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经人群筛选出90例原发性高血压新病例,按影响血流变学指标的主要人群特征配比90例正常人为对照,进行血流变学与原发性高血压病因联系的研究。单因素分析结果表明,全血粘度(高切及低切)、血浆粘度、相对粘度(高切及低切与血浆粘度之比)、红细胞聚集指数,病例组均显著高于对照组(P<0.01);红细胞刚性指数、血沉K值、红细胞压积,血红蛋白含量,病例组也显著高于对照组(P<0.05)。多元条件Logistic回归分析在P=0.1水平上选进的变量是全血粘度(高切)、血浆粘度及红细胞刚性指数。研究结果表明原发性高血压的血流变学变化主要是血浆粘度升高及红细胞变形能力降低。因此,防治高血压时需考虑到血流变的特征,改善血流变状况,即降低血浆粘度及增加红细胞的变形性。
A total of 90 new cases of essential hypertension were screened out by the population. According to the characteristics of the main population influencing hemorrheological indexes, 90 normal controls were used as control group to study the relationship between hemorrheology and essential hypertension. Univariate analysis showed that whole blood viscosity (high and low cut), plasma viscosity, relative viscosity (ratio of high and low cut to plasma viscosity), erythrocyte aggregation index and case group were significantly higher than those in control group (P < 0.01). The erythrocyte rigidity index, erythrocyte sedimentation rate, hematocrit, hemoglobin content were also significantly higher in the case group than those in the control group (P <0.05). Multivariate Logistic regression analysis The variables selected at P = 0.1 were whole blood viscosity (high shear), plasma viscosity, and erythrocyte rigidity index. The results show that the changes of hemorheology in essential hypertension are mainly the increase of plasma viscosity and the decrease of erythrocyte deformability. Therefore, the prevention and treatment of hypertension need to take into account the characteristics of blood rheology, improve blood flow conditions, that reduce plasma viscosity and increase the deformability of red blood cells.