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家族性低磷抗D性佝偻病是性联遗传、常染色体隐性遗传或散发的代谢病。可严重影响小儿生长发育。经典治疗方法采用磷酸盐合剂和大剂量维生素D治疗,但部分病例效果欠佳,而且可并发甲状旁腺功能亢进和肾脏钙盐沉着。近年来国外推荐采用生长激素(GH)、噻嗪类利尿剂和24,25二羟维生素D(VD)治疗,可防止甲状旁功能亢进的产生和减少磷酸盐合剂剂量。今将我们的治疗和随访结果报道如下。
Familial low-phosphorus anti-D rickets is sexually transmitted, autosomal recessive or sporadic metabolic diseases. Can seriously affect the growth and development of children. Classical treatment with phosphate mixture and high-dose vitamin D treatment, but some cases of ineffective, and can be complicated by hyperparathyroidism and renal calcium calm. In recent years, foreign recommended the use of growth hormone (GH), thiazide diuretics and 24,25 dihydroxy vitamin D (VD) treatment, to prevent the generation of parathyroidism and reduce the dosage of phosphate mixture. The results of our treatment and follow-up are reported below.