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目的探讨沈阳市某二级甲等医院妇产科围手术期患者使用抗菌药物的不良事件,以促进妇产科围手术期患者抗菌药物的合理应用。方法采用分层随机抽样法,选取2010年6月至2011年6月于沈阳市某二级甲等医院妇产科手术期患者300例的临床病历资料为研究对象,提取其中抗菌药物的使用信息,分析抗菌药物不良事件的发生情况(本研究遵循的程序得到参与单位的医学伦理委员会批准,并与研究对象签署临床研究知情同意书)。结果 300例妇产科围手术期患者中,103例出现抗菌药物不良事件,发生率为34.33%。以头孢菌素类药物(53.32%,201/377)发生抗菌药物不良反应为主,不良反应的类型以消化道反应(28.12%,106/377)多见,Ⅰ类,Ⅱ类手术切口的抗菌药物合理应用较不合理应用的不良事件发生率明显低。结论促进沈阳市某二级甲等医院妇产科围手术期患者抗菌药物的合理使用可明显降低抗菌不良事件的发生率。
Objective To investigate the adverse events of antimicrobial agents used in perioperative patients in gynecology and obstetrics department of a second class hospital in Shenyang to promote the rational use of antimicrobial agents in perioperative patients. Methods A stratified random sampling method was used to select the clinical records of 300 cases of obstetrics and gynecology during the operation from June 2010 to June 2011 in Shenyang Grade A First Affiliated Hospital. The information of antibiotics was extracted (The procedures followed in this study were approved by the Medical Ethics Committee of the participating units and sign informed consent of clinical research with the study participants). Results Among the 300 cases of perioperative patients in obstetrics and gynecology, 103 cases appeared antimicrobial adverse events, the incidence was 34.33%. The main adverse reactions of antimicrobial agents were cephalosporins (53.32%, 201/377). The types of adverse reactions were more common in gastrointestinal reactions (28.12%, 106/377), antibacterials in Ⅰ and Ⅱ surgical incisions The reasonable incidence of adverse drug use of drugs is less reasonable. Conclusion The rational use of antimicrobial agents in perioperative patients in gynecology and obstetrics department of a second class hospital in Shenyang can significantly reduce the incidence of antimicrobial adverse events.