论文部分内容阅读
目的探讨颅外异位垂体腺瘤(EPA)的临床病理特点。方法搜集并分析3例EPA的临床病理、免疫组化及电镜特点。结果 3例均为男性,平均年龄50岁;2例位于鼻腔,1例位于鼻咽顶正中。镜下见形态单一的肿瘤细胞排列呈实性或器官样、梁索状,瘤细胞巢间分布纤细血管,核多形性、核分裂象及坏死罕见。3例肿瘤细胞Syn、Cg A和CD56均强(+),2例分别为ACTH、TSH(+)。结论 EPA是一种罕见的预后良好的肿瘤,结合临床(特异内分泌症状)、影像学(蝶鞍外中线部位界清肿块)及病理组织学(神经内分泌及垂体激素标记物阳性)可确诊,手术完全切除可治愈,不能全切者术后辅以放疗或药物治疗。
Objective To investigate the clinicopathological features of extracranial ectopic pituitary adenoma (EPA). Methods The clinical pathology, immunohistochemistry and electron microscopic features of 3 EPA patients were collected and analyzed. Results All the 3 cases were male, with an average age of 50 years. Two cases were located in the nasal cavity and one case was located in the middle of the nasopharynx. Microscopic see a single tumor cells arranged in a solid or organ-like, cord-like, nesting neoplasms slender blood vessels, nuclear pleomorphism, mitosis and necrosis rare. Three cases of tumor cells Syn, Cg A and CD56 were strong (+), two cases were ACTH, TSH (+). Conclusion EPA is a rare tumor with good prognosis. Combined with clinical (specific endocrine symptoms), imaging (clear mass outside the sella of the sellae) and histopathology (neuroendocrine and pituitary hormone markers positive) can be diagnosed, surgery Complete resection can be cured, can not be cut by postoperative radiotherapy or drug therapy.