论文部分内容阅读
组织缺氧是实体瘤的一个主要特征,它引起肿瘤细胞胞外酸性环境的形成.肿瘤细胞通过质子感知的G蛋白偶联受体(G protein-coupled receptors,GPCRs)或质子感知的离子通道感知其胞外的酸性环境,并激活多条细胞内信号通路,影响细胞功能.肿瘤最致命的方面在于其转移能力,肿瘤转移程度与肿瘤细胞迁移能力呈正相关.因此,对胞外酸性与肿瘤细胞迁移扩散之间关系的深入研究将有助于发现更多新的抗肿瘤转移药物.本文就肿瘤酸性微环境的形成、肿瘤细胞的质子感知机制、胞外酸性环境对肿瘤浸润转移的影响及如何将肿瘤pH调节应用于癌症治疗等方面的内容予以综述.
Hypoxia is a major feature of solid tumors that cause the extracellular acidic environment of tumor cells to be detected by tumor cells via proton-sensing G protein-coupled receptors (GPCRs) or proton-sensing ion channels Its extracellular acidic environment, and activate multiple intracellular signaling pathways, affecting cell function .Tumor is the deadliest aspect of its ability to transfer, the degree of tumor metastasis and tumor cell migration was positively correlated.Therefore, the extracellular acid and tumor cells In-depth study of the relationship between migration and diffusion will help to find more new antitumor drugs.In this article, the formation of tumor acidic microenvironment, the proton sensing mechanism of tumor cells, the impact of extracellular acidic environment on tumor invasion and metastasis and how The application of tumor pH regulation in the treatment of cancer is reviewed.