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目的 探索放疗并用５ － Ｆｕ 增敏对治疗中晚期食道癌疗效的影响。方法 对食道癌患者进行前瞻性随机分组研究，均采用钴－ ６０ 机或加速器６ ＭＶ 的Ｘ 线常规三野放射，总剂量６０ － ７０ Ｇｙ 。放疗并口服组，放疗同时服用１３９ － ３ 至放疗结束；放疗并静脉滴注组，每周１ 次持续２４ｈ 静脉滴注５ － Ｆｕ１ ．０ｇ 至放疗结束。结果 并用５ － Ｆｕ 组放疗３６ － ４０ Ｇｙ 及放疗６０ － ７０Ｇｙ 的肿瘤消退显效率与单纯放疗组比较，有显著性差异。ｌａ 生存率并用５ － Ｆｕ 组与单纯放疗组比较也有显著性差异。而持续静脉滴注５ － Ｆｕ 组近期疗效优于口服１３９ － ３组。结论 放疗并用５ － Ｆｕ 持续静脉滴注治疗中晚期食道癌可以提高疗效。
Objective To explore the effect of radiotherapy and 5-sensitized sensitization on the curative effect of advanced esophageal cancer. Methods A randomized, prospective randomized study of patients with esophageal cancer was performed using conventional X-rays of cobalt-60 or accelerator 6 MV with a total dose of 60-70 Gy. Radiotherapy and oral group, radiotherapy at the same time taking 139 - 3 to the end of radiotherapy; radiotherapy and intravenous infusion group, weekly for 24h intravenous infusion of 5 - Fu1. 0g to end of radiotherapy. Results There was a significant difference in the efficacy rate of tumor regression between 36 - 40 Gy and 60 - 70 Gy of radiotherapy combined with 5-Fu group compared with radiotherapy alone group. There was also a significant difference in the la survival rate between the 5-Fu group and the radiotherapy alone group. The short-term efficacy of continuous intravenous infusion of 5-Fu was superior to that of oral 139-3. Conclusion The use of 5-FU continuous intravenous infusion for the treatment of advanced esophageal cancer can improve the curative effect.