Intravitreal bevacizumab versus triamcinolone acetonide for macular edema due to branch retinal vein

来源 :中华医学杂志(英文版) | 被引量 : 0次 | 上传用户:litao343243581
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Background Branch retinal vein occlusion (BRVO) is a common retinal vascular disorder of the elderly and both intravitreal triamcinolone acetonide (TA) and intravitreal bevacizumab were reported to be effective. The purpose of this study was to compare intravitreal bevacizumab with intravitreal TA for the treatment of macular edema resulting from BRVO.Methods The retrospectively comparative interventional study included a bevacizumab group of 34 BRVO patients (1.25 mg bevacizumab) and a TA group of 34 BRVO patients (4.0 mg TA), and the two groups were matched by baseline best corrected visual acuity (BCVA). Examinations were designed to be carried out at 1 day, 3 days, 1 month, 2 months, 3 months, 6 months and 1 year after each injection. The mean follow-up was (148.43±130.56) days. Main outcome parameters were BCVA and morphometric measurements of the macula obtained by optical coherence tomography.Results In all follow-ups, the mean changes of BCVA (LogMAR) between two groups were not significantly different (P >0.10). Similarly, the rates of patients who got BCVA improvement >2 lines or lost BCVA >2 lines were not significantly different, either (P >0.10). In both groups, compared with baseline, the mean central macular thickness (CMT) got reduction from 4 weeks to 1 year after initial injection, however, which lost statistical significance at 6-month follow-up in TA group (P=0.25) and lost significance at 3-month and 6-month follow-up in bevacizumab group (P=0.07, 0.21). The mean CMT between two groups differed at 3-month follow-up (P <0.01), while almost kept parallel in other follow-ups (all P >0.40). In TA group, retinal pigment epithelium tear occurred in 1 eye at 8 weeks after initial injection and 12 eyes (35.3%) got intraocular pressure >21 mmHg. In bevacizumab group, no severe complications were observed.Conclusion For BRVO, intravitreal bevacizumab versus intravitreal TA causes a similar increase in visual acuity and reduction of macular edema (except 3-month follow-up) with minor complications during 1 year.
其他文献
1992—2007我院收治100例糖尿病和并心脏疾病患者,现就其临床特点进行回顾分析。
通过现场关于电磁干扰方面的故障问题的阐述,简要介绍电磁干扰的产生、形成电磁干扰的三个要素以及电磁干扰的五种抑制方法。 Through the on-the-spot elaboration on the
针对半主动制导体制的地空导弹武器系统组网,研究了协同探测/跟踪、协同制导、跨火力单元控制等基本的网络化作战模式,并就具体应用进行了效能仿真,分析提出了地空导弹武器系
空间电子产品的电绝缘性能构成了航天器电信号传输和作用的边界,需要在航天器的研制流程中进行试验验证.文章针对部件级以上电绝缘试验选择和设计实施过程中需要解决的关键性
期刊
铁路线路在长期运营过程中,道床易形成板结、排水不畅、翻浆冒泥、路基沉降、线位变化等基础病害。必须要对线路道床定期清筛中修,进行彻底的基础病害整治。全路第六次大提速
事情的发展完全在潘树德的预料之中.张南方的工厂因为缺了A厂和B厂的零部件,一下子瘫痪了,装了一半的汽车像一条条死鱼趴在工厂里不动,成了一堆堆废铁,不少都堆在荒草丛中,任
Background A Chinese family with autosomal dominant central areolar choroidal dystrophy (CACD) was identified.The purpose of this study was to collect the clini