砷及其化合物在工农业生产中应用较广,砷不仅是一种毒物,而且具有致癌性。我们曾收治过一例职业砷中毒所致的皮肤癌继发肺、脑转移的患者。现介绍如下,以供参考。 病例介绍 患者陈××,男性43岁 病历号120268于1951～1952年从事砷冶炼工作,其工艺是将矿石(雄黄)加上石灰石、焦炭、木炭在300～400℃的温度下冶炼生成三氧化二砷,每两天出一炉,约1,800～2,100公斤。操作时戴一般纱布口罩,手套,工作服,冶炼时炉门密闭不严,故有多量砷蒸气及粉尘逸散。 患者在此情况下操作,鼻唇沟、腋窝,阴囊等皮肤经常发红,出水泡破溃。工作半年多后双手掌及足跟出现皮肤角化结节,不痛不痒,胸背皮肤逐渐出现黑白斑点,且日渐增多,同时半有咽干,咽疼,但无腹痛, Arsenic and its compounds are widely used in industrial and agricultural production. Arsenic is not only a poison, but also carcinogenic. We have admitted to a case of occupational arsenic poisoning caused by skin cancer secondary to lung and brain metastases. Now introduced as follows, for reference. Case description Patient Chen × ×, male 43 years old Medical records 120268 In 1951 ~ 1952 engaged in arsenic smelting work, the process is the ore (realgar) plus limestone, coke, charcoal at 300 ~ 400 ℃ smelting temperature generated arsenic trioxide, Every two days out of a furnace, about 1,800 ~ 2,100 kg. Operation wearing a normal gauze masks, gloves, overalls, smelting furnace door closed lax, so a large amount of arsenic vapor and dust escape. Patients operating in this case, the nasolabial fold, armpits, scrotum and other skin often redness, blisters rupture. Work more than six months after the palm and heel of the skin appear keratinized nodules, itching, chest and back skin gradually black and white spots, and increasing, and half with throat, sore throat, but no abdominal pain,