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目的 探讨血清胃泌素 (GAS) ,癌胚抗原 (CEA)对大肠癌的诊断意义。方法 采用放射免疫法 (RIA)测定大肠癌患者 ( 4 5例 )及正常组 ( 3 0例 )的GAS和CEA水平。结果 大肠癌组GAS显著高于CEA(P <0 0 5 ) ,术后GAS ,CEA阳性率差异无显著性。衰竭期患者GAS显著下降 ,GAS阳性率与CEA阳性率差异有显著性。结论 血清GAS ,CEA都可作为筛选大肠癌的一项客观指标 ,但GAS敏感性明显高于CEA。GAS对判断手术疗效及病情发展有参考价值。
Objective To investigate the diagnostic value of serum gastrin (GAS) and carcinoembryonic antigen (CEA) in colorectal cancer. Methods The levels of GAS and CEA in patients with colorectal cancer (45 cases) and normal controls (30 cases) were determined by radioimmunoassay (RIA). Results The GAS in colorectal cancer group was significantly higher than that in CEA group (P <0.05). There was no significant difference in the positive rates of GAS and CEA after operation. GAS in patients with failure during the decline significantly, GAS positive rate and CEA positive rate difference was significant. Conclusions Serum GAS and CEA can be used as an objective index in screening colorectal cancer, but the sensitivity of GAS is significantly higher than that of CEA. GAS has the reference value for judging the curative effect and developing of the disease.