噻嗪类利尿剂的降压地位在80年代之前一直被推荐为第一线降压药。该药价廉易得,降压疗效确实,尤其对单纯收缩期高血压疗效更为显著。但该类药物也有一定缺陷,即对糖、脂代谢有一定的干扰,易引起电解质素乱等。90年代之后由于钙拮抗剂及血管紧张素转换酶抑制剂的兴起,认为这两类药物不仅降压疗效较好,且有逆转左心室肥厚,改善糖、脂代谢的作用,因而受到临床医生及患者的普遍欢迎,大有后来者居上之势,噻嗪 The antihypertensive status of thiazide diuretics has been recommended as first-line antihypertensive drugs until the 1980s. The drug is cheap and easy, and antihypertensive effect is indeed, especially for the treatment of isolated systolic hypertension is more significant. However, these drugs also have certain shortcomings, that is, sugar, lipid metabolism have some interference, easy to cause electrolyte disorders and so on. Since the 1990s, due to the rise of calcium antagonists and angiotensin converting enzyme inhibitors, these two drugs are considered not only to be effective in antihypertensive effect, but also to reverse left ventricular hypertrophy and improve glucose and lipid metabolism. Therefore, The general popularity of patients, a lot of latecomers living on the trend, thiazide