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目的探讨急性脑卒中患者尿酸水平变化及与脑卒中危险因素的关系。方法选择住院治疗的急性脑卒中患者183例(脑卒中组),测定其急性期血清尿酸、血糖、血脂、同型半胱氨酸及血压等水平,与同期健康体检者73例(对照组)进行比较,比较尿酸与脑卒中危险因素的关系。结果脑卒中组与对照组比较,脑卒中组体重指数(BMI)、三酰甘油、低密度脂蛋白、血糖、收缩压、舒张压、血糖、血清尿酸浓度明显高于对照组(P<0.05),脑卒中组高密度脂蛋白低于对照组(P<0.05);尿酸与BMI、三酰甘油、低密度脂蛋白、血糖呈显著正相关(P<0.05),与性别呈显著负相关(P<0.05);以尿酸为应变量,其他指标为自变量进行多元逐步回归分析显示,尿酸与BMI、收缩压、低密度脂蛋白、血糖呈正相关,与性别、呈负相关(P<0.05)。结论急性脑卒中患者尿酸水平高于对照组,尿酸与急性脑卒中危险因素关系密切,有可能在急性脑卒中发生发展过程中起到一定作用。
Objective To investigate the changes of uric acid in patients with acute stroke and its relationship with the risk factors of stroke. Methods A total of 183 hospitalized acute stroke patients (stroke group) were enrolled in this study. Serum uric acid, blood glucose, blood lipids, homocysteine and blood pressure were measured during the acute phase of stroke. The results were compared with 73 healthy subjects (control group) Compare and compare the relationship between uric acid and stroke risk factors. Results Compared with the control group, the body mass index (BMI), triglyceride, LDL, blood glucose, systolic blood pressure, diastolic blood pressure, blood glucose and serum uric acid in the stroke group were significantly higher than those in the control group (P <0.05) (P <0.05). There was a significant positive correlation between uric acid and BMI, triglyceride, low density lipoprotein and blood glucose (P <0.05), and negatively correlated with gender <0.05). Multiple regression analysis showed that uric acid was positively correlated with BMI, systolic blood pressure, low density lipoprotein, blood glucose and gender, with uric acid as a dependent variable and other indicators as independent variables (P <0.05). Conclusion The level of uric acid in patients with acute stroke is higher than that in control group. Uric acid is closely related to the risk factors of acute stroke, which may play a role in the development of acute stroke.