Pioglitazone相关论文
Pioglitazone exacerbates the hepatic steatosis and suppresses serum cholesterol clearance in two ani
Aim: Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) frequently coexist as they share the p......
Neuroprotective effects of pioglitazone is associated with PPARγ-mediated inhibition of NF-κB signal
Objective To investigate the neuroprotective actions of pioliotazone (Piog) and the effects of Piog-mediated PPART activ......
Introduction: Parkinsons disease(PD)is a chronic neurodegenerative disease of the central nervous system.The main pathol......
Development and validation of an improved LC-MS/MS method for simultaneous quantitation of metformin
Objective To support the pharmacokinetic study of metformin (MET) hydroehloride/pioglitazone (PIO) hydroehloride tablet,......
Aims.Accumulating evidence indicates that thiazolidinediones(TZDs)may exert protective effects in terms of atrial fibril......
Simultaneous determination of glimepiride and pioglitazone in human plasma by liquid chromatography-
The rapid,sensitive,and selective liquid chromatography–electrospray ionization–tandem mass spectrometry method (LC–E......
PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of ty
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Pioglitazone ameliorates memory deficits in streptozotocin-induced diabetic mice:involvement of amyi
Aim: To examine the effects of pioglitazone, a PPART agonist, on memory performance and brain amyloidogenesis in strepto......
PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of ty
OBJECTIVE Pioglitazone, known as a peroxisome proliferator-activated receptor γ (PPARγ) agonist, is used to treat type......
Introduction:Inflammatory processes have been implicated in the pathophysiology and progression of mood disorders,and an......
Effectiveness and safety of different doses of pioglitazone in psoriasis: a meta-analysis of randomi
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Effects of pioglitazone on expressions of matrix metalloproteinases 2 and 9 in kidneys of diabetic r
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目的探讨PPAR-γ激动剂吡格列酮(piglitazone,PGZ)对恶性间皮瘤细胞增殖活力的影响及其作用机制。方法于2019年12月,选择人双相型恶性......
目的探讨吡格列酮联合生活方式干预对代谢综合征(MS)患者控脂控压效果的影响。方法选取2013年3月至2015年3月MS患者65例,随机分为观......
目的探讨不同药物联合治疗方案在青春期多囊卵巢综合征患者中的疗效和安全性。方法选取2015年1月至2017年1月60例青春期多囊卵巢综......
Although microRNAs(miRNAs) have been intensively studied in cardiac fibrosis,their roles in drug-mediated anti-fibrotic ......
Rosiglitazone(RZ)和Pioglitazone(PZ)治疗2型糖尿病都很安全且耐受性较好。然而,美国德克萨斯州立大学糖尿病研究所的研究人员对......
目的 明确过氧化小体增殖剂激活型受体γ(PPARγ)激活剂对实验性缺血脑组织细胞凋亡的影响,并对其可能的NO路径机制进行探索分析.......
目的 观察吡格列酮联合二甲双胍治疗2型糖尿病的临床疗效.方法 152例2型糖尿病患者按数字表法随机分为对照组和治疗组各76例,对照......
目的探讨3T3-L1前脂肪细胞分化过程中新基因URB[(upregulated in bombesin receptor subtype-3(BRS-3)-deficient mice,缺乏铃蟾肽......
目的 观察吡咯列酮联合瑞格列奈治疗外源性胰岛素抗体阳性的2型糖尿病肾病的疗效.方法 将44例外源性胰岛素抗体阳性的糖尿病肾病患......
目的观察吡格列酮对氧化型低密度脂蛋白(ox-LDL)诱导的TPH-1巨噬细胞脂联素受体1(AdipoR1)表达的影响。方法给予不同浓度的吡格列......
目的比较罗格列酮与格列美脲联合胰岛素治疗首次诊断2型糖尿病的临床疗效及安全。方法研究对象选取初诊T2DM患者共150例,采用随机数......
冠心病的发病机制与脂质浸润、炎症损伤、内皮细胞功能障碍等密切相关.即使在无糖尿病的冠心病患者中,胰岛素抵抗也是普遍存在的,......
目的 探讨吡格列酮在重症急性胰腺炎发病机制中与凋亡激活的关系.方法 将80只SD大鼠按随机表法分为急性坏死性胰腺炎组(ANP组)、假......
罗格列酮和吡格列酮同属为噻唑烷二酮类胰岛素增敏剂,主要用于2型糖尿病的治疗。罗格列酮因可能增加心血管事件风险于2010年被限用......
Development and validation of a high throughput LC–MS/MS method for simultaneous quantitation of pio
Management of cardiovascular risk factors in diabetes demands special attention due to their co-existence. Pioglitazone ......
1例47岁男性糖尿病患者因血糖控制欠佳给予二甲双胍(1 g、2次/d)、阿卡波糖(50 mg、3次/d)和吡格列酮(15 mg、1次/d)三联降糖治疗......
Effect of Pioglitazone on Transdifferentiation of Preosteoblasts from Rat Bone Mesenchymal Stem Cell
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Despite the fact that non-alcoholic fatty liver disease (NAFLD) and its severe clinical forms [non-alcoholic steatohepat......
目的 观察吡格列酮对2型糖尿病患者氧化应激和抗氧化指标的影响并探讨其可能机制.方法 选择符合WHO 1999年诊断标准的2型糖尿病患......
目的 探讨非诺贝特联合吡格列酮在初诊青少年代谢综合征(MS)治疗中的近期及远期疗效.方法 按国际糖尿病联盟(IDF)关于MS防治建议诊......
目的 研究叉头状转录因子01( FoxO1)及吡格列酮干预对高胰岛素诱导的肝癌HepG-2细胞葡萄糖消耗的影响及机制.方法 1×10-6 mol/L胰......
目的:比较两种联合方案治疗2型糖尿病的成本效果。方法:2型糖尿病62例,随机分为A组(格列美脲联合二甲双胍,33例)、B组(格列美脲联合吡......
目的 探讨吡格列酮(Pio)调节树突状细胞(DC)黏附和迁移功能的可能机制.方法 体外培养人外周血单核细胞来源的DC和人脐静脉内皮细胞......
目的 探讨吡格列酮对糖耐量减低合并非酒精性脂肪肝患者血清脂联素变化的影响.方法 吡格列酮组46例糖耐量减低合并非酒精性脂肪肝......
盐酸Pioglitazone为一种口服治疗非胰岛素依赖型糖尿病的药物。大鼠和狗的血清药动学研究鉴定出6种代谢物。其中认为有药理活性的......
目的探讨非酒精性脂肪性肝病(NAFLD)人群胰岛素抵抗(IR)与血浆抵抗素(resistin)水平的变化及吡格列酮干预对其影响。方法①筛选136......
目的:观察吡格列酮对老年原发性高血压伴糖耐量异常患者血糖、血脂、动态脉压指数(PPI)和动态动脉硬化指数(AASI)及血浆氨基末端脑......
目的 研究吡格列酮对ERK1/2与Bcl-2信号转导通路在大鼠心肌缺血再灌注损伤中的作用.方法 取半日龄到一日龄Wistar大鼠幼鼠心室肌细......
目的研究吡格列酮联合醋酸环丙孕酮对多囊卵巢综合症患者胰岛素抵抗及生殖激素水平的影响。方法选择2013年10月—2014年12月来我院......
As a widely prescribed anti diabetic drug,pioglitazone belongs to class IΙ under BCS and exhibits low and variable oral......
目的探讨噻唑烷二酮(th iazolid ined ione,TZD)类药物吡格列酮对糖尿病大鼠心肌的保护作用.方法应用链脲佐菌素(streptozotoc in,......
目的 探讨过氧化物增殖物激活受体-γ激动剂吡格列酮能否依靠其抗炎作用改善持续性心房颤动(AF)患者电复律的效果.方法 前瞻性入选......
目的:探讨吡格列酮对老年糖耐量低减患者(IGT)内皮功能的影响。方法:选取56例老年糖耐量正常者(NGT)及60例老年糖耐量低减患者(IGT......
目的:在动物疼痛模型上,观察过氧化物酶体增殖剂激活受体γ(peroxisome proliferator-activated receptor gamma,PPARγ)激动剂吡格列酮......