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肝脏清除药物主要取决于三个因素,即肝血流量、血内药物结合度及药物代谢酶活力。静注高度提纯的药物如利多卡因、吗啡和心得安时,肝血流量是清除药物的主要因素。反之,不易由肝清除的药如安替吡啉、华法林等,其清除则取决于药物代谢酶活力或与血内某些成份的结合度(或两者兼备)。口服药的清除只能反映肝内药物代谢活力,而与全身廓清决定因素无关。甲氛咪脏是一种强力的肝药物代谢酶抑制剂。许多药物同甲佩咪肌合用可抑制这些药的排除,如安替毗琳、
Liver clearance depends mainly on three factors, namely liver blood flow, blood drug binding and drug metabolism enzyme activity. Intravenous highly purified drugs such as lidocaine, morphine and propranolol, liver blood flow is the main factor in drug clearance. Conversely, drugs that are not easily cleared by the liver, such as antipyrine, warfarin and the like, depend on the activity of the drug-metabolizing enzyme or the degree of binding to certain components in the blood (or both). Oral drug clearance can only reflect the metabolism of intrahepatic drug metabolism, but with systemic clearance factors have nothing to do. Mucuna is a powerful liver drug metabolizing enzyme inhibitor. Many drugs combined with Jia Mimi inhibit the exclusion of these drugs, such as antipyrine,