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目的:研究地黄内生真菌的代谢产物。方法:采柱色谱方法进行分离纯化,并根据化合物的理化性质和波谱数据鉴定其结构。结果:从地黄内生真菌代谢产物中分离并鉴定了10个化合物:2,4-dihydroxy-2’,6-diacetoxy-3’-methoxy-5’-methyldiphenyl ether(1),paecilospirone(2),α-axetylorcino(3),2-methoxy-1,8-dimethyl-xanthen-9-one(4),4-hydroxy-α-lapachone(5),enalin A(6),2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran(7),p-hydroxyethyl-phenol(8),2,4-dihydroxy-3,5,6-trimethyl-methylbenzoate(9),3-isopropenyl-(z)-monomethyl maleate(10)。结论:化合物1为新的二苯醚类化合物,其显示了一定的细胞毒和抗真菌活性。
Objective: To study the metabolites of endophytic fungi of Rehmannia glutinosa. Methods: The column chromatography was used to separate and purify the compounds, and their structures were identified according to the physicochemical properties and spectral data of the compounds. Results: Ten compounds were isolated and identified from endophytic fungi metabolites of Dihuang: 2,4-dihydroxy-2 ’, 6-diacetoxy-3’-methoxy-5’-methyldiphenyl ether (1), paecilospirone Alpha-axetylorcino (3), 2-methoxy-1,8-dimethyl-xanthen-9- one (4), 4-hydroxy- alpha-lapachone (5), enalin A (7), p-hydroxyethyl-phenol (8), 2,4-dihydroxy-3,5,6-trimethyl- methylbenzoate (9), 3-isopropenyl- ) -monomethyl maleate (10). Conclusion: Compound 1 is a new diphenyl ether compound that shows some cytotoxic and antifungal activity.