Objective: To compare the application effects of percutaneous percutanuous intervertebral foraminal BEIS (Broad Easy Immediate Surgery) technique on patients with lumbar disc herniation. Methods: Eighty-six patients with lumbar disc herniation treated in the Seventh People' s Hospital of Zibo City from Mary 2016 to May 2019 were selected and divided into control group and study group according to the simple randomization of random number table method, with 43 cases in each group. Patients in control group were treated with lamina fenestration while patients in study group were treated with percutanuous intervertebral foraminal BEIS technique. The surgical status and hospital stay, complications, pain [Visual Analogue Scale (VAS) score], Oswestry Disability Index (ODI) score and quality of life [MOS 36-item Short From Health Survey (SF-36)] were compared between the two groups. Results: The surgical time in study group was longer than that in control group, and the incision length was shorter than that in control group, and the fluoroscopy frequency was more than that in control group, and the intraoperative blood loss was less than that in control group, and the hospital stay was shorter than that in control group (P0.05). There were statistically significant differences in the between-group effects, time-point effects and interaction effects of VAS pain score (P<0.05), and the VAS pain score in study group at 24 h and 1 w after surgery was significantly lower than that in control group (P0.05), and there were statistically significant differences in the time-point effects (P<0.05). There were statistically significant differences in the between-group effects, time-point effects and interaction effects of SF-36 score (P<0.05). The ODI score at 3 months after surgery in study group was lower than that in control group while the SF-36 score was higher than that in control group (P<0.05). Conclusion: Compared with traditional lamina fenestration, percutanuous intervertebral foraminal BEIS technique has the advantages of less trauma and quicker postoperative recovery in the treatment of lumbar disc herniation. Self-made simple locator can reduce the fluoroscopy frequency, improve the accuracy of positioning, further reduce surgical trauma and promote recovery of patients.