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从临床分离获得口腔常见厌氧菌135株,其中92％的产黑素类杆菌,79％的韦荣氏球菌,90％的梭杆菌,95％的放线菌,95％的消化链球菌和消化球菌菌株对交沙霉素敏感。交沙霉素对以上厌氧菌株和产黑素类杆菌、中间类杆菌,牙龈类杆菌,脆弱类杆菌国际标准菌株的MIC为0.4～1.6μg/ml。口腔急性感染患者的临床症状、白细胞总数和中性粒细胞分类计数在服用交沙霉素后2～5天明显改善和好转,病灶内细菌培养阳性率或细菌数量明显下降,并且未出现不良反应。实验结果表明交沙霉素有较强的抗厌氧菌作用和良好的临床疗效。
135 strains of common oral anaerobic bacteria were obtained from clinical isolates, of which 92% of melanobacteria, 79% of vesicular bacteria, 90% of Fusobacterium, 95% of actinomycetes, 95% of peptostreptococcus and Peptostreptococcus strains are sensitive to jasminemycin. Josamycin on the above anaerobic strains and the production of melanobacteria, Bacteroides, gingivalis, Bacteroides fragilis international standard strains of MIC 0.4 ~ 1.6μg / ml. Clinical symptoms, the total number of leukocytes and neutrophil count in patients with acute oral infections were significantly improved and improved 2 to 5 days after taking jasamycin, the positive rate of bacterial culture in the lesion or the number of bacteria decreased significantly, and no adverse reactions . The experimental results show that josamycin has a strong anti-anaerobic effect and good clinical efficacy.