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近年来对已有转移的结肠直肠癌开展了肿瘤减负荷手术,即尽量切除肿瘤组织以减少宿主的肿瘤细胞负荷量,随后再采用辅助疗法以控制残留癌肿的生长。作者对51例结肠直肠癌和130例阑尾癌已伴有腹膜癌病者进行了上述肿瘤减负荷手术,包括6种不同的腹膜切除术(大网膜和脾切除、左上腹腹膜切除、右上腹腹膜切除、小网膜和胆囊切除、盆腔腹膜和直肠乙状结肠切除、胃窦切除)。均在术中腹腔内注入5-氟尿嘧啶,初期剂量为15mg/kg加入1L1.5％葡萄糖腹腔透析液中,术后2、3、4和5天给
In recent years, tumor-reducing surgery has been carried out on colorectal cancers that have metastasized, that is, tumor tissues are removed as much as possible to reduce the host tumor cell load, and then adjuvant therapy is used to control the growth of residual cancer. The authors performed the above-mentioned tumor-reducing surgery on 51 cases of colorectal cancer and 130 cases of appendix cancer with peritoneal cancer, including 6 different peritoneum resections (omental and splenectomy, upper left abdominal peritoneum, right upper quadrant Peritoneal excision, omentum and cholecystectomy, pelvic peritoneum and rectosigmoid resection, gastric antrum resection). Intraperitoneal injection of 5-fluorouracil was performed during the operation. The initial dose of 15 mg/kg was added to 1 L of 1.5% glucose peritoneal dialysate and given on days 2, 3, 4 and 5 after surgery.