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目的：研究云南西双版纳大花哥纳香（ＧｏｎｉｏｔｈａｌａｍｕｓｇｒｉｆｆｉｔｈｉＨｏｏｋ．ｆ．ｅｔＴｈｏｍｓ）茎皮的化学成分。方法：利用各种色谱技术进行分离纯化，根据理化性质和光谱数据等进行结构鉴定。结果：从大花哥纳香茎皮的乙醇提取物中分离得到５个化合物，其结构分别鉴定为５，７二羟基双氢黄酮（Ｉ），５，６２Ｈ６苯乙烯吡喃２酮（ＩＩ），（５Ｒ，６Ｓ，７Ｒ，８Ｒ）７羟基８苯基四氢呋喃骈［３，２ｂ］２Ｈ吡喃２酮（ＩＩ），（６Ｒ，７Ｒ，８Ｒ）６（７，８二羟基苯乙基）５，６２Ｈ吡喃２酮（ＩＶ），（４Ｓ，５Ｒ，６Ｓ，７Ｓ，８Ｒ）６羟基７（α乙酰氧基苄基）四氢呋喃骈［３，２ｂ］呋喃２酮（Ｖ）。初步药理实验表明，化合物ＩＩ～Ｖ有一定的抗肿瘤活性。结论：化合物Ｖ为新化合物，化合物Ｉ和ＩＩ是首次从该植物中分离得到。
Objective: To study the chemical composition of bark of Goniothalamus griffithiHook.f.etThoms in Xishuangbanna, Yunnan. Methods: Separation and purification were performed by various chromatographic techniques. Structure identification was performed based on physicochemical properties and spectral data. RESULTS: Five compounds were isolated from the ethanol extract of G. sinensis bark, and their structures were identified as 5,7-dihydroxydihydroflavone (I), 5,6-2H-6-strypyrazole respectively. 2-Methylketone (II),(5R,6S,7R,8R)-7-Hydroxy-8-Phenyl-tetrahydrofuran[3,2-b]-2H-pyran-2-ketone(II), (6R,7R,8R)-6(7,8-dihydroxyphenethyl)-5,6-2H-pyran-2-ketone (IV), (4S,5R,6S,7S,8R) 6-Hydroxy-7-(α-acetoxybenzyl)-tetrahydrofuran 骈[3,2-b]furan-2-keto (V). Preliminary pharmacological experiments showed that Compounds II-V have certain antitumor activity. Conclusion: Compound V is a new compound, and compounds I and II are isolated from this plant for the first time.