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动脉粥样硬化是严重危害人类健康的重大疾病。新近的研究表明，前蛋白转化酶枯草溶菌素9作为降解低密度脂蛋白受体的重要分子，影响前蛋白转化酶枯草溶菌素9－低密度脂蛋白受体途径导致低密度脂蛋白代谢异常，与动脉粥样硬化形成的关系密切。现就前蛋白转化酶枯草溶菌素9影响动脉粥样硬化研究进展做一综述。“,”Atherosclerosis is a serious disease that is harmful to human health .Proprotein convertase subtilisin/kexin type 9 ( PCSK9) , a newly recognized protein , which plays a key role in cholesterol homeostasis by enhancing the degradation of hepatic low -density lipoprotein receptor and causing marked increases in low-density lipoprotein cholesterol concentration and atherosclerosis .This review pro-vides important links between PCSK 9, low-density lipoprotein receptor and the mechanisms of atherosclerosis .